Proguanil is used to prevent infections caused by Plasmodium that is responsible for Malaria.
What is Proguanil?
Proguanil prevents the reproduction of some malaria parasite species (Plasmodium falciparum and Plasmodium vivax) by inhibiting the Dihydrofolate reductase enzyme, whose activity is required for parasite reproduction.
How should Proguanil be taken?
Proguanil is administered only with prescription, in tablet form and usually in combination with another drug.
It is generally recommended to take it after a meal, with a glass of water. The dose is variable, depending on the patient. To be effective, treatment should be started at least 24 hours prior to potential exposure to Plasmodium.
Side effects associated with Proguanil
Among the possible adverse effects are included:
- Diarrhea
- Headache
- Loss of appetite
- Ulcers or sores in the mouth
- Nausea
- Temporary hair loss
You should immediately contact a doctor if:
- Skin rash
- Itchy skin
- Abdominal or chest pain
- Blood in urine
- Lower back pain
- Pain or burning during urination
- Vomiting
Contraindications and warnings associated with the use of Proguanil
Moreover, before starting the treatment it is important to tell your doctor if:
- You have any allergy to the active substance, to other components or to other drugs or foods
- You are taking other medications, herbal remedies and supplements, in particular goldthioglucose, dicoumarol, warfarin and chloroquine
- You suffer (or have suffered) from kidney problems
- You had or have scheduled typhoid vaccine
- You are pregnant or breastfeeding
