Flucytosine is used to treat serious infections from Candida or Cryptococcus responsible for septicemia, to endocarditis, infections of the urinary tract, meningitis and lung infections.
What is Flucytosine?
The exact mechanism of how Flucytosine function is not known. It is assumed that once it enters into the fungal cells, it is modified as to be incorporated in their RNA and inhibits both DNA and RNA synthesis. It also seems to inhibit enzymatic activity of the fungus.
How should Flucytosine be taken?
Typically, Flucytosine is administered orally, in multiple doses and during the day. The exact dosage necessary depends from case to case. Its use is linked to that of Amfotericina B.
Side effects associated with Flucytosine
Possible side effects of Flucytosine include the following:
- Rash, skin redness and itching
- Sore throat and fever
- Bleeding or bruising
- Tiredness or weakness
- Confusion
- Hallucination
- Increased skin sensitivity to sunlight
It is important to consult your doctor if the drug triggers:
- Abdominal pains
- Diarrhea
- Loss of appetite
- Nausea or vomiting
- Dizziness or feeling faint or lightheaded
- Drowsiness
- Headache
Contraindications and warnings associated with the use of Flucytosine
Before taking Flucytosine, it is advised to inform your doctor:
- If you have any allergies to the active substance, its excipients or any other drugs
- If you are taking any medicinal products, herbal remedies or supplements. Mentioning in particular clozapine and deferiprone
- If you suffer (or have suffered) from certain diseases
- If you are pregnant or breastfeeding
