Amrinone is used for the treatment of congestive heart failure in the short term. The condition is characterized by venous stasis and reduced blood flow from the left ventricle, which results in fatigue, shortness of breath, abdominal discomfort and edema. Amrinone based therapies must be of a short duration (24 hours) because of the toxic effects.
What is Amrinone?
Amrinone is a drug that acts based on the inhibition of Phosphodiesterase enzymes. By inhibiting the action of these enzymes it leads to an increase in cyclic AMP and then gives birth to vasodilatory and cardiac properties.
How should Amrinone be taken?
Amrinone is administered intravenously.
Side effects associated with Amrinone
Side effects resulting from the use of amrinone are mainly nausea and vomiting. Bone marrow toxicity and hepatic thrombocytopenia may occur as well as arrhythmias.
Contraindications and warnings associated with the use of Amrinone
This medication should not be given to patients with hypersensitivity to the active ingredient, a substance that can cause extra activeness if not used sensibly. It can cause asthmatics, allergic-type reactions and severe asthmatic attacks. Special care should be taken when using this drug in patients with impaired liver or kidney function. The safety and efficacy of this drug in children has not yet been established; therefore, it is not recommended for use in children. Moreover, it is not suitable for women who are pregnant or breastfeeding.
