{"id":51936,"date":"2018-06-19T09:10:42","date_gmt":"2018-06-19T09:10:42","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=51936"},"modified":"2018-06-19T09:11:14","modified_gmt":"2018-06-19T09:11:14","slug":"cisaprid","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/cisaprid\/","title":{"rendered":"Cisaprid"},"content":{"rendered":"<p>Cisapid deluje putem stimulacije receptora u nervnom sistemu u sprezi sa gastrointestinalnim sistemom. Stimuli\u0161e osloba\u0111anje neuotransmitera acetilholina putem pove\u0107anja motilinosti gornjeg patija digestivnog trakta bez stimulacije gastri\u010dne, bilijarne i pankreati\u010dne sekrecije. Usled toga nastaje ubrzano pra\u017enjenje \u017eeluda\u010dnog i cevnog sadr\u017eaja.<\/p>\n<p>&nbsp;<\/p>\n<h2>\u0160ta je Cisaprid?<\/h2>\n<p>Cisaprid se primenjuje u le\u010denju gastroezofagealnog refluksa pogotovo ako je udru\u017een sa pojavom pe\u010denja u grudnom ko\u0161u tokom no\u0107nih sati i otpornog na ostale vidove le\u010denja.<\/p>\n<p>&nbsp;<\/p>\n<h2>Kada se Cispaod primenjuje ?<\/h2>\n<p>&nbsp;<\/p>\n<p>Cisaprid se administrira peroralno u formi tableta ili vodenog rastvora. Naj\u010de\u0161\u0107e se primenjuju 4 doze dnevno, otprilike 15 minuta pre ve\u010dernjeg obroka.<\/p>\n<p>&nbsp;<\/p>\n<h2>Ne\u017eeljeni efekti udru\u017eeni sa Cisapridom<\/h2>\n<p>Cisaprid je udru\u017een sa postojanjem ozbiljnih ne\u017eeljenih efekata, kao \u0161to su sr\u010dani poreme\u0107aji i letalni ishod. Naro\u010dito mogu nastati:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Aritmije, pogotovo u prisustvu predisponiraju\u0107ih faktora, kao \u0161to su ventikulane aritmije, renalna insuficijencija, kongestivna sr\u010dana insuficijencija, produ\u017een QT interval, ishemijska bolest srca, respiratorna insuficijencija i nekontrolisan elektrolitni disbalans<\/li>\n<li>Ventrikularna fibrilacija<\/li>\n<li>QT produ\u017eenje<\/li>\n<li>Tahikardija<\/li>\n<li>Torsades de pointes<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Rizik za nastanik ovih ne\u017eeljenih efekata pove\u0107an je kod osoba na medikamentima koji mogu produ\u017eiti QT interval, inhibisati citohom P450 kao i redukovati nivo serumskih elektrolita.<\/p>\n<p>&nbsp;<\/p>\n<p>U slu\u010daju pojave bolova u grudnom ko\u0161u ili poreme\u0107aja vida tokom primene Cisparida neophodno je pravovremeno informisati ordiniraju\u0107eg lekara.<\/p>\n<h2>Ostali ne\u017eeljeni efekti udru\u017eeni sa primenom Cisaprida mogu biti:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Konstipacija<\/li>\n<li>Dijareja<\/li>\n<li>Glavobolja<\/li>\n<li>Rinoreja<\/li>\n<li>\u017deluda\u010dne tegobe<\/li>\n<li>Ka\u0161alj<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>Kontraindikacije i mere opreza udru\u017eene sa primenom Cisaprida<\/h2>\n<p>&nbsp;<\/p>\n<p>14 Jula 2000 godine, po osnovu postojanja te\u0161kih ne\u017eeljenih efekata, proizvo\u0111a\u010d je samovoljno povukao sa tr\u017ei\u0161ta lek Cisaprid sa ameri\u010dkog tr\u017ei\u0161ta.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Na evropskom tr\u017ei\u0161tu dalji promet aktivne supstance ovog leka je suspendovan pre svega u Nema\u010dkoj, Britaniji; dok je Ministrastvo za Farmakovigilancu i Informacije o Lekovima limitiralo indikaciono podru\u010dje primene ovog leka pre svega u slu\u010daju gastropareze kod odraslih i gastroezofagealnog oboljenja u ranom detinjstvu.<\/p>\n<p>&nbsp;<\/p>\n<p>Lek mo\u017ee izazvati pospanost te je neophodno izbegavati njegovu primenu pre upravljanja motornim vozilom ili rukovanjem ru\u010dnim ma\u0161inama. Pretpostavlja se da upotreba alkohola mo\u017ee uticati na ve\u0107i stepen pospanosti usled interakcije sa aktivnom supstancom leka.<\/p>\n<p>&nbsp;<\/p>\n<h2>Pre upotrebe Cisaprida, neophodno je informisati lekara o slede\u0107em:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>U slu\u010daju postojanja alergije na Cisaprid ili druge lekove<\/li>\n<li>U slu\u010daju upotrebe dugih lekova ili biljnih preparata. Naro\u010dito lekova u terapiji anksioznosti, antiholinergika, antikoagulanasam azitromicina, cimetidina, dirtromicina, mikonazola, sedativa i vitamina<\/li>\n<li>U slu\u010daju postojanja gastrointestinalnih poreme\u0107aja ili krvare\u0107ih ulkusa<\/li>\n<li>U slu\u010daju trudno\u0107e ili dojenja<\/li>\n<\/ul>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1795],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cisaprid - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/cisaprid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cisaprid - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Cisapid deluje putem stimulacije receptora u nervnom sistemu u sprezi sa gastrointestinalnim sistemom. Stimuli\u0161e osloba\u0111anje neuotransmitera acetilholina putem pove\u0107anja motilinosti gornjeg patija digestivnog trakta bez stimulacije gastri\u010dne, bilijarne i pankreati\u010dne sekrecije. Usled toga nastaje ubrzano pra\u017enjenje \u017eeluda\u010dnog i cevnog sadr\u017eaja. &nbsp; \u0160ta je Cisaprid? 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Stimuli\u0161e osloba\u0111anje neuotransmitera acetilholina putem pove\u0107anja motilinosti gornjeg patija digestivnog trakta bez stimulacije gastri\u010dne, bilijarne i pankreati\u010dne sekrecije. Usled toga nastaje ubrzano pra\u017enjenje \u017eeluda\u010dnog i cevnog sadr\u017eaja. &nbsp; \u0160ta je Cisaprid? 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