{"id":51815,"date":"2018-06-18T12:28:52","date_gmt":"2018-06-18T12:28:52","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=51815"},"modified":"2019-01-14T09:37:17","modified_gmt":"2019-01-14T09:37:17","slug":"gemcitabin","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/","title":{"rendered":"Gemcitabin"},"content":{"rendered":"<p>Gemcitabin predstavlja antineoplasti\u010dni agens koji se metaboli\u0161e intracelularno. Njegova citotoksi\u010dna aktivnost posledica je inhibicije sinteze DNA \u0107elija i njihova dva glavna metabolita, difluorosicitidindifosfata i difluorodeoscitidintrifosfata kao i diflurodeoscitidintrifosfata.<\/p>\n<h2>\u0160ta je Gemcitabin?<\/h2>\n<p>Gemcitabin predstavlja antineoplasti\u010dni, antimetabolitni lek koji pripada pirimidnskoj grupi. Primenjuje se tokom le\u010denja razli\u010ditif formi karcinoma, pe svega:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Kacinoma mokra\u0107ne be\u0161ike<\/li>\n<li>Karcinoma dojke<\/li>\n<li>Karcinoma ovarijuma<\/li>\n<li>Karcinoma plu\u0107a (nesitno\u0107elijski karcinom)<\/li>\n<li>Karcinom pankreasa<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Neophodno je lek administrirati sam ili u kombinaciji sa dugim antikancerskim lekovima.<\/p>\n<p>&nbsp;<\/p>\n<h2>Kako se primenjuje Gemcitabin ?<\/h2>\n<p>&nbsp;<\/p>\n<p>Gemcitabin se primenjuje:<\/p>\n<ul>\n<li>Intravenski (infuziono)<\/li>\n<li>Intravezikalno (putem katetera)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Ne\u017eeljeni efekti Gemcitabina<\/p>\n<p>Kao i ostali hemotrapijski lekovi, Gemcitabin mo\u017ee izazvati pojavu malaksalosti (astenije) i smanjenje apetita, koje mo\u017ee biti u vidu bla\u017ee ili te\u017ee forme. Ova slabost mo\u017ee biti povezana sa postojanjem anemije. Ne\u017eeljeni efekti mogu varirati od individual do individual, u zavisnosti od individualne tolerancije.<\/p>\n<p>&nbsp;<\/p>\n<h2>Naj\u010de\u0161\u0107i ne\u017eeljeni efekti udru\u017eeni sa primenom :<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Temporary reduction in the production of blood cells by the bones (the decrease in red blood marrow causes decreased hemoglobin and therefore anemia, the decrease in white blood cells facilitates the development of infections, decreased platelets causes bruising or bleeding) Your blood cells will then increase steadily and will usually have returned to normal within 21-28 days after initiation of therapy;<\/li>\n<li>Mu\u010dnina i povra\u0107anje;<\/li>\n<li>Simptomi sli\u010dni prehladi.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Re\u0111i efekti mogu biti:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Privremena redukcija funkcije jetre ( koja \u0107e se pri kraju tretmana normalizovati)<\/li>\n<li>Promene ko\u017ee sli\u010dne erupciji akni, koje mogu svrbeti<\/li>\n<li>Bol ili ulkusi usta, sa ili bez poreme\u0107aja ukusa<\/li>\n<li>Dijareja;<\/li>\n<li>Pospanost;<\/li>\n<li>Gubitak kose;<\/li>\n<li>Promene u bubre\u017enoj funkciji ( povremene i reverziblne)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Kontraindikacije i mere opreza udru\u017eene sa primenom Gemcitabina<\/h2>\n<p>&nbsp;<\/p>\n<p>Odre\u0111eni lekovi mogu uticati na primenu Gemcitabina, te se savetuje adekvatna komunikacija sa onkologom u cilju pravilne upotrebe lekova i konsultacijje radi daljeg le\u010denja.<\/p>\n<p>&nbsp;<\/p>\n<p>Neophodan je oprez usled solane radijacije: hemoterapeutici se prostiru kroz cirkulaciju, uklju\u010duju\u0107i ko\u017eu, te\u00a0 produ\u017een kontakt sa sun\u010devim zracima izaziva cvenilo, osip i opekotine. Nadalje, ne preporu\u010duje se dojenje tokom le\u010denja Gemcitabinom.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1795],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gemcitabin - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gemcitabin - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Gemcitabin predstavlja antineoplasti\u010dni agens koji se metaboli\u0161e intracelularno. 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Primenjuje se tokom le\u010denja razli\u010ditif formi karcinoma, pe svega: &nbsp; Kacinoma mokra\u0107ne be\u0161ike Karcinoma dojke [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/\" \/>\n<meta property=\"og:site_name\" content=\"Humanitas.net\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HumanitasInternational\/\" \/>\n<meta property=\"article:modified_time\" content=\"2019-01-14T09:37:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<meta name=\"twitter:site\" content=\"@humanitasmilano\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/\",\"url\":\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/\",\"name\":\"Gemcitabin - Humanitas.net\",\"isPartOf\":{\"@id\":\"https:\/\/www.humanitas.net\/sr\/#website\"},\"datePublished\":\"2018-06-18T12:28:52+00:00\",\"dateModified\":\"2019-01-14T09:37:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/#breadcrumb\"},\"inLanguage\":\"sr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humanitas.net\/sr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Wikis\",\"item\":\"https:\/\/www.humanitas.net\/sr\/wiki\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Gemcitabin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humanitas.net\/sr\/#website\",\"url\":\"https:\/\/www.humanitas.net\/sr\/\",\"name\":\"Humanitas.net\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.humanitas.net\/sr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humanitas.net\/sr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"sr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.humanitas.net\/sr\/#organization\",\"name\":\"Humanitas\",\"url\":\"https:\/\/www.humanitas.net\/sr\/\",\"sameAs\":[\"https:\/\/www.facebook.com\/HumanitasInternational\/\",\"https:\/\/twitter.com\/humanitasmilano\"],\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sr\",\"@id\":\"https:\/\/www.humanitas.net\/sr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.humanitas.net\/content\/uploads\/2017\/05\/logo-news-.png\",\"contentUrl\":\"https:\/\/www.humanitas.net\/content\/uploads\/2017\/05\/logo-news-.png\",\"width\":314,\"height\":61,\"caption\":\"Humanitas\"},\"image\":{\"@id\":\"https:\/\/www.humanitas.net\/sr\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gemcitabin - Humanitas.net","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/","og_locale":"en_US","og_type":"article","og_title":"Gemcitabin - Humanitas.net","og_description":"Gemcitabin predstavlja antineoplasti\u010dni agens koji se metaboli\u0161e intracelularno. Njegova citotoksi\u010dna aktivnost posledica je inhibicije sinteze DNA \u0107elija i njihova dva glavna metabolita, difluorosicitidindifosfata i difluorodeoscitidintrifosfata kao i diflurodeoscitidintrifosfata. \u0160ta je Gemcitabin? Gemcitabin predstavlja antineoplasti\u010dni, antimetabolitni lek koji pripada pirimidnskoj grupi. Primenjuje se tokom le\u010denja razli\u010ditif formi karcinoma, pe svega: &nbsp; Kacinoma mokra\u0107ne be\u0161ike Karcinoma dojke [&hellip;]","og_url":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/","og_site_name":"Humanitas.net","article_publisher":"https:\/\/www.facebook.com\/HumanitasInternational\/","article_modified_time":"2019-01-14T09:37:17+00:00","twitter_card":"summary","twitter_site":"@humanitasmilano","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/","url":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/","name":"Gemcitabin - Humanitas.net","isPartOf":{"@id":"https:\/\/www.humanitas.net\/sr\/#website"},"datePublished":"2018-06-18T12:28:52+00:00","dateModified":"2019-01-14T09:37:17+00:00","breadcrumb":{"@id":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/#breadcrumb"},"inLanguage":"sr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/gemcitabin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.humanitas.net\/sr\/"},{"@type":"ListItem","position":2,"name":"Wikis","item":"https:\/\/www.humanitas.net\/sr\/wiki\/"},{"@type":"ListItem","position":3,"name":"Gemcitabin"}]},{"@type":"WebSite","@id":"https:\/\/www.humanitas.net\/sr\/#website","url":"https:\/\/www.humanitas.net\/sr\/","name":"Humanitas.net","description":"","publisher":{"@id":"https:\/\/www.humanitas.net\/sr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.humanitas.net\/sr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sr"},{"@type":"Organization","@id":"https:\/\/www.humanitas.net\/sr\/#organization","name":"Humanitas","url":"https:\/\/www.humanitas.net\/sr\/","sameAs":["https:\/\/www.facebook.com\/HumanitasInternational\/","https:\/\/twitter.com\/humanitasmilano"],"logo":{"@type":"ImageObject","inLanguage":"sr","@id":"https:\/\/www.humanitas.net\/sr\/#\/schema\/logo\/image\/","url":"https:\/\/www.humanitas.net\/content\/uploads\/2017\/05\/logo-news-.png","contentUrl":"https:\/\/www.humanitas.net\/content\/uploads\/2017\/05\/logo-news-.png","width":314,"height":61,"caption":"Humanitas"},"image":{"@id":"https:\/\/www.humanitas.net\/sr\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/wiki\/51815"}],"collection":[{"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/wiki"}],"about":[{"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/types\/wiki"}],"author":[{"embeddable":true,"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/users\/11"}],"version-history":[{"count":0,"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/wiki\/51815\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/media?parent=51815"}],"wp:term":[{"taxonomy":"wiki-categories","embeddable":true,"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/wiki-categories?post=51815"},{"taxonomy":"wiki-types","embeddable":true,"href":"https:\/\/www.humanitas.net\/sr\/wp-json\/wp\/v2\/wiki-types?post=51815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}