{"id":51793,"date":"2018-06-18T11:53:49","date_gmt":"2018-06-18T11:53:49","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=51793"},"modified":"2018-06-18T11:54:36","modified_gmt":"2018-06-18T11:54:36","slug":"labetalol","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/labetalol\/","title":{"rendered":"Labetalol"},"content":{"rendered":"<p>Labetalol je antihipertenzivni lek koji deluje putem simultane blokade dva tipa receptora, alfa i beta-adrenergi\u010dkih lekova. Deluje putem inhibicije prvog nivoa malih arterija putem redukcije rezistencije na kvni protok, dok inhibicija beta-receptora redukuje ne\u017eeljene efektie vazodilatacije u srcu.<\/p>\n<p>&nbsp;<\/p>\n<h2>\u0160ta je Labetalol ?<\/h2>\n<p>Labetalol se primenjuje u slu\u010daju povi\u0161en krvnog pritiska (tako\u0111e tokom trudno\u0107e) kao i nakon infarkta miokarda. Tako\u0111e se primenjuje u slu\u010daju hipertenzivne krize, hipotenzije i op\u0161te anestezije.<\/p>\n<p>&nbsp;<\/p>\n<h2>Kako se primenjuje Labetalol ?<\/h2>\n<p>Labetalol se primenjuje u formi tableta od 10 mg u vidu\u00a0 inicijalne doze podeljene\u00a0 u dve pojedina\u010dne doze (ujutru i uve\u010de), uvek na pun \u017eeludac. Posledi\u010dno, doza se mo\u017ee pove\u0107ati na 200 mg dva puta na dan. Ipak, ne isklju\u010duje se mogu\u010dnost rezistentnih slu\u010dajeva te ovo stanj mo\u017ee zahtevati \u010dak i dve doze od 400 mg\/dan. Maksimalna dnevna doza koja se mo\u017ee administrirati mo\u017ee biti 2.4 gr na dan.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>Ne\u017eeljeni efekti udru\u017eeni sa primenom Labetalola<\/h2>\n<p>Potencijalni ne\u017eeljeni efekti udru\u017eeni sa Labetalolom mogu biti:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Promene u sastavu krvi<\/li>\n<li>Angioedem<\/li>\n<li>Astenija<\/li>\n<li>Povi\u0161ene transaminaze<\/li>\n<li>Bradikardija<\/li>\n<li>Bronhospazam<\/li>\n<li>Nazalna kongestija<\/li>\n<li>O\u0161te\u0107enje jetre<\/li>\n<li>Depresija<\/li>\n<li>Dispnea<\/li>\n<li>Poreme\u0107aji mi\u0161i\u0107ne sprovodljivosti<\/li>\n<li>Poreme\u0107aji mikcije<\/li>\n<li>Poreme\u0107aji vida<\/li>\n<li>Epigastri\u010dni bol<\/li>\n<li>Edem \u010dlanka<\/li>\n<li>Hepatitis<\/li>\n<li>Osip<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Lichenoidne erupcije<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Temperatura<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Mravinjanje skalpa<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Posturalna hipotenzija<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u017dutica<\/li>\n<li>Letargija<\/li>\n<li>Sistemski eritemski lupus<\/li>\n<li>Glavobolja<\/li>\n<li>Nemogu\u0107nost ejakulacije<\/li>\n<li>Toksi\u010dna miopatija<\/li>\n<li>Mu\u010dnina<\/li>\n<li>Hepati\u010dna nekroza<\/li>\n<li>Pozitivna antinuklearna antitela<\/li>\n<li>Svrab<\/li>\n<li>Akutna urinarna retencija<\/li>\n<li>Suvo\u0107a nazalne mukoze<\/li>\n<li>Suvo\u0107a i iritacija o\u010diju<\/li>\n<li>Lucidni snovi<\/li>\n<li>Znojenja<\/li>\n<li>Tremor<\/li>\n<li>Vrtoglavica<\/li>\n<li>Povra\u0107anje<\/li>\n<\/ul>\n<h2>Kontraindikacije i mere\u00a0 opreza udru\u017eene sa primenom Labetalol<\/h2>\n<p>Labetalol je kontraindikovan u slu\u010daju:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Diabeti\u010dna acidoza<\/li>\n<li>Dojenje<\/li>\n<li>Atrioventrikularni blok drugog i tre\u0107eg stepena<\/li>\n<li>Te\u017ei stepen bradikardije<\/li>\n<li>Sr\u010dana isnuficijencija tokom le\u010denja digitalisom<\/li>\n<li>Te\u017ei stepen bubre\u017ene insuficijencije<\/li>\n<li>Hipersenzitivnost na aktivnu supstancu ili neke druge sastojke (uklju\u010duju\u0107i i laktozu)<\/li>\n<li>Kardiogeni \u0161ok i drugi poreme\u0107aji udru\u017eeni sa te\u0161kom i dugotrajnom hipotenzijom<\/li>\n<li><\/li>\n<\/ul>\n<h2>Tako\u0111e je neophodno obratiti pa\u017enju u slu\u010daju:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Astme i bronhospazma<\/li>\n<li>O\u0161te\u0107enja jetre<\/li>\n<li>O\u0161te\u0107enja srca<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Lek mo\u017ee intereagovati sa slede\u0107im supstancama:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Blokatori kalcijumskih kanala tipa verapamil<\/li>\n<li>A klasa I antiaritmika<\/li>\n<li>Amjodaron<\/li>\n<li>Anestetici<\/li>\n<li>Tricikli\u010dni antidepresivi<\/li>\n<li>Cimetidin<\/li>\n<li><\/li>\n<\/ul>\n<p>Nadalje, budu\u0107i da mo\u017ee izazvati pojavu vtoglavice i letargije, labetalol se primenjuje oprezno u slu\u010daju upravljanja motornim vozilom i ru\u010dnim ma\u0161inama.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1795],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Labetalol - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/labetalol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Labetalol - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Labetalol je antihipertenzivni lek koji deluje putem simultane blokade dva tipa receptora, alfa i beta-adrenergi\u010dkih lekova. 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