{"id":51759,"date":"2018-06-18T11:19:42","date_gmt":"2018-06-18T11:19:42","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=51759"},"modified":"2018-06-18T11:20:22","modified_gmt":"2018-06-18T11:20:22","slug":"milrinone","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/milrinone\/","title":{"rendered":"Milrinone"},"content":{"rendered":"<p>Milrinon se primenjuje u le\u010denju kongestivne sr\u010dane insuficijencije, stanja koje se karakteri\u0161e venskom stazom i redukcijom krvnog protoka iz levog ventrikula izazivaju\u0107i simptome kao \u0161to su astenija, dispnea, edem i abdominalni diskomfor. Usled toksi\u010dnih efekata koji se mogu javiti, ovaj lek se ne primenjuje u periodu du\u017eem od 48 sati.<\/p>\n<p>&nbsp;<\/p>\n<h2>\u0160ta je Milrinon ?<\/h2>\n<p>Milrinon je lek \u010diji mehanizam dejstva se bazira na inhibiciji enzima fosfodiesteraze III: \u010dija aksija rezultuje pove\u0107anjem intracelularnog nivoa cikli\u010dnog AMP kao i kalcijuma i miokardijalne kontraktilnosti.<\/p>\n<p>&nbsp;<\/p>\n<h2>Kako se primenjuje Milrinon ?<\/h2>\n<p>Milrinon se mo\u017ee primenjivati peroralno ili putem intravenske\u00a0 ili intramuskularne injekcije.<\/p>\n<p>&nbsp;<\/p>\n<h2>Ne\u017eelljeni efekti udru\u017eeni sa\u00a0 primenom Milrinona<\/h2>\n<p>&nbsp;<\/p>\n<p>Naj\u010de\u0161\u0107i ne\u017eeljeni lekovi udru\u017eeni sa primenom Milrinona mogu biti hipokalijemija, tremor i trombocitopenija.<\/p>\n<p>&nbsp;<\/p>\n<h2>Kontraindikacije\u00a0 i mere opreza\u00a0 udru\u017eene sa primenom Milrinona<\/h2>\n<p>&nbsp;<\/p>\n<p>Le\u010denje Milrinonom se ne peporu\u010duje kod pacijenata sa te\u0161kom opstrukcijom arterija, poreme\u0107aja sr\u010danih zalistaka ili kod individual koje su nedavno pre\u017eivele sr\u010dani napad. Posebna pa\u017enje se posve\u0107uje administraciji lekova koji se doziraju kod osoba sa poreme\u0107ajem funkcije jetre ili bubrega.<\/p>\n<p>&nbsp;<\/p>\n<p>Jo\u0161 uvek ne postoje studije koje potvr\u0111uju sigurnost i efikasnost ovih lekova kod dece te se ne preporu\u010duje u pedijatrijskoj praksi. Nadalje, njegova upotreba se izbegava kod trudnica\u00a0 ili dojilja.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1795],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Milrinone - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/sr\/wiki\/aktivni-sastojci\/milrinone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Milrinone - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Milrinon se primenjuje u le\u010denju kongestivne sr\u010dane insuficijencije, stanja koje se karakteri\u0161e venskom stazom i redukcijom krvnog protoka iz levog ventrikula izazivaju\u0107i simptome kao \u0161to su astenija, dispnea, edem i abdominalni diskomfor. 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