{"id":52575,"date":"2018-06-29T10:18:11","date_gmt":"2018-06-29T10:18:11","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=52575"},"modified":"2018-06-29T10:18:23","modified_gmt":"2018-06-29T10:18:23","slug":"52575","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/52575\/","title":{"rendered":"Everolimus"},"content":{"rendered":"<p>Everolimus se utilizeaz\u0103 pentru a trata unele forme de cancer mamar la femeile aflate \u00een postmenopauz\u0103 care nu au r\u0103spuns a\u0219a cum se a\u0219tepta la alte terapii medicamentoase. Este, de asemenea, utilizat pentru a trata anumite tumori neuroendocrine pancreatice progresive, cancer renal avansat rezistente la tratamentul cu sorafenib sau sunitinib \u0219i unele forme de angiomiopolipom, renal, scleroz\u0103 tuberculoas\u0103 complex\u0103 \u0219i astrocitom de celule gigantice subependimale. Everolimus este, de asemenea, utilizat la anumi\u021bi pacien\u021bi pentru a preveni rejetul de organe dup\u0103 un transplant de rinichi sau ficat.<\/p>\n<h2>Ce este Everolimus?<\/h2>\n<p>Everolimus blocheaz\u0103 proliferarea celulelor \u0219i induce apoptoza (moartea celular\u0103) prin inhibarea activit\u0103\u021bii proteinei mTOR. De asemenea, scade produc\u021bia de noi vase de s\u00e2nge (angiogenez\u0103) \u0219i absorb\u021bia glucozei. Everolimus ac\u021bioneaz\u0103 ca un imunosupresor prin blocarea ac\u021biunii anumitor celule sanguine \u00een sistemul imunitar. Aceste celule pot determina organismul s\u0103 resping\u0103 organul transplantat.<\/p>\n<p>Cum ar trebui luat Everolimus?<\/p>\n<p>Everolimus se administreaz\u0103 pe cale oral\u0103. Pentru tratamentul cancerului de s\u00e2n, anumite medicamente sunt combinate cu exemestan. \u00cen general, totu\u0219i, tratamentul imunosupresiv implic\u0103 combinarea anumitor medicamente \u0219i ciclosporin\u0103.<\/p>\n<h2>Reac\u021bii adverse asociate cu Everolimus<\/h2>\n<p>Everolimus poate \u00eencetini vindecarea r\u0103nilor chirurgicale, reduce capacitatea organismului de a lupta \u00eempotriva infec\u021biilor, de a reduce cantitatea de sperm\u0103 produs\u0103 \u0219i de a promova debutul hiperglicemiei sau diabetului. Poate fi asociat \u0219i cu apari\u021bia unei pneumonii neinfec\u021bioase \u0219i cu un risc crescut de apari\u021bie a cancerelor (\u00een special a cancerului de piele).<\/p>\n<p>Printre celelalte posibile efecte secundare ale everolimus se num\u0103r\u0103 urm\u0103toarele:<br \/>\n\u2022\u00a0 Durere \u00een spate, bra\u021be sau picioare<br \/>\n\u2022\u00a0 Constipa\u021bie<br \/>\n\u2022\u00a0 Diaree<br \/>\n\u2022\u00a0 Ame\u021beli<br \/>\n\u2022\u00a0 Somnolen\u021ba<br \/>\n\u2022\u00a0 Durere de cap<br \/>\n\u2022\u00a0 Pierderea poftei de m\u00e2ncare<br \/>\n\u2022\u00a0 Grea\u021b\u0103<br \/>\n\u2022\u00a0 V\u0103rs\u0103turi<br \/>\n\u2022\u00a0 Dureri sau disconfort la nivelul stomacului<br \/>\n\u2022\u00a0 Oboseal\u0103 sau sl\u0103biciune<br \/>\n\u2022\u00a0 Insomnie<br \/>\n\u2022\u00a0 Probleme sexuale la b\u0103rba\u021bi<\/p>\n<p>Este important s\u0103 contacta\u021bi imediat un medic dac\u0103 ave\u021bi:<br \/>\n\u2022\u00a0 Eczem\u0103<br \/>\n\u2022\u00a0 Urticarie<br \/>\n\u2022\u00a0 Respira\u0163ie dificil\u0103<br \/>\n\u2022\u00a0 Ap\u0103sare \u00een piept sau \u00een dureri \u00een piept<br \/>\n\u2022\u00a0 Umflarea gurii, a fe\u021bei, a buzelor sau a limbii<br \/>\n\u2022\u00a0 R\u0103gu\u0219eal\u0103 neobi\u0219nuit\u0103<br \/>\n\u2022\u00a0 Scaun s\u00e2ngeros<br \/>\n\u2022\u00a0 Durere, umflare, \u00eenro\u0219ire sau sensibilitate la picioare sau a pulpelor<br \/>\n\u2022\u00a0 Modific\u0103ri ale aspectului<br \/>\n\u2022\u00a0 Confuzie<br \/>\n\u2022\u00a0 Le\u0219in<br \/>\n\u2022\u00a0 B\u0103t\u0103i rapide sau neregulate ale inimii<br \/>\n\u2022\u00a0 Febr\u0103 persistent\u0103, frisoane sau durere \u00een g\u00e2t<br \/>\n\u2022\u00a0 Halucina\u021bii<br \/>\n\u2022\u00a0 Modific\u0103ri ale dispozi\u021biei sau comportamentului<br \/>\n\u2022\u00a0 Dureri musculare sau sl\u0103biciune<br \/>\n\u2022\u00a0 Debutul tusei sau agravarea tusei existente<br \/>\n\u2022\u00a0 Amor\u021beal\u0103 sau furnic\u0103turi<br \/>\n\u2022\u00a0 Scaune u\u0219oare<br \/>\n\u2022\u00a0 Constipa\u021bie sever\u0103 sau persistent\u0103, diaree, grea\u021b\u0103, dureri de stomac sau v\u0103rs\u0103turi<br \/>\n\u2022\u00a0 Ame\u021beli sau dureri de cap severe sau persistente<br \/>\n\u2022\u00a0 Oboseal\u0103 sau sl\u0103biciune sever\u0103 sau persistent\u0103<br \/>\n\u2022\u00a0 Dificult\u0103\u021bi de respira\u021bie sau alte probleme de respira\u021bie<br \/>\n\u2022\u00a0 Blistere \u00een gur\u0103 sau pe limb\u0103<br \/>\n\u2022\u00a0 Umflarea stomacului<br \/>\n\u2022\u00a0 Umflarea bra\u021belor, a m\u00e2inilor, a picioarelor sau a gleznelor<br \/>\n\u2022\u00a0 Noduli limfatici umfla\u021bi<br \/>\n\u2022\u00a0 Hiperglicemie<br \/>\n\u2022\u00a0 Probleme de rinichi sau urinare<br \/>\n\u2022\u00a0 Tremors<br \/>\n\u2022\u00a0 \u00cenvine\u021bire sau s\u00e2ngerare<br \/>\n\u2022\u00a0 Probleme de vedere<br \/>\n\u2022\u00a0 Pete albe \u00een gur\u0103<br \/>\n\u2022\u00a0 Icter<\/p>\n<h2>Contraindica\u021bii \u0219i avertismente asociate cu utilizarea Everolimus<\/h2>\n<p>Everolimus este contraindicat \u00een cazul transplantului de inim\u0103, a unor afec\u021biuni ereditare sau dac\u0103 lua\u021bi delavirdin\u0103.<\/p>\n<p>\u00cen timpul tratamentului cu acest medicament este necesar s\u0103 se evite consumul de grapefruit sau s\u0103 se bea sucul. \u00cen plus, femeile \u00een v\u00e2rst\u0103 fertil\u0103 trebuie s\u0103 utilizeze metode eficace de control al na\u0219terii \u00een timp ce iau acest medicament \u0219i la 8 s\u0103pt\u0103m\u00e2ni dup\u0103 \u00eentreruperea tratamentului.<\/p>\n<p>Everolimus poate afecta capacitatea de a conduce vehicule sau de a folosi utilaje periculoase. Acest efect secundar poate fi agravat de alcool sau alte medicamente.<\/p>\n<p>\u00cenainte de a \u00eencepe tratamentul cu everolimus, este important s\u0103 spune\u021bi medicului dumneavoastr\u0103 dac\u0103:<\/p>\n<p>\u2022\u00a0 Ave\u021bi alergii la substan\u021ba activ\u0103, la excipien\u021bii acesteia sau la alte medicamente, alimente sau substan\u021be diferite<br \/>\n\u2022\u00a0 Lua\u021bi orice alte medicamente, remedii pe baz\u0103 de plante sau suplimente. Men\u021bion\u00e2nd \u00een special: al\u021bi agen\u021bi imunosupresori, inhibitori ai ECA, fibra\u021bi, inhibitori ai HMG-CoA reductazei, medicamente care pot d\u0103una ficatului, aprepitant, antifungice azole, delavirdin\u0103, digoxin\u0103, diltiazem, antibiotice macrolide, nefazodon\u0103, nicardipin\u0103, inhibitori de proteaz\u0103, telitromicin\u0103, verapamil, carbamazepin\u0103, dexametazon\u0103, efavirenz, hidantoine, nevirapin\u0103, fenobarbital, primidon\u0103 sau rifamicin\u0103 hipericum<br \/>\n\u2022\u00a0 suferi\u021bi (sau a\u021bi suferit) de diabet sau hiperglicemie, colesterol ridicat sau trigliceride \u00eenalte, maduva osoas\u0103 sau probleme de s\u00e2nge, sistemul imunitar sl\u0103bit, probleme pulmonare sau de respira\u021bie, infec\u021bii, boli hepatice sau cancer de piele<br \/>\n\u2022\u00a0 Ave\u021bi un istoric familial de cancer de piele<br \/>\n\u2022\u00a0 A\u021bi primit recent vaccinuri vii<br \/>\n\u2022\u00a0 A\u021bi fost recent \u00een contact cu persoanele care au primit vaccinuri vii<br \/>\n\u2022\u00a0 Sunte\u021bi gravid\u0103 sau al\u0103pta\u021bi<\/p>\n<p>Este important s\u0103 informa\u021bi medicii, chirurgii \u0219i stomatologii despre orice tratament \u00een curs de desf\u0103\u0219urare cu everolimus.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1869],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Everolimus - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/52575\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Everolimus - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Everolimus se utilizeaz\u0103 pentru a trata unele forme de cancer mamar la femeile aflate \u00een postmenopauz\u0103 care nu au r\u0103spuns a\u0219a cum se a\u0219tepta la alte terapii medicamentoase. 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