{"id":52475,"date":"2018-06-25T12:32:53","date_gmt":"2018-06-25T12:32:53","guid":{"rendered":"https:\/\/www.humanitas.net\/?post_type=wiki&#038;p=52475"},"modified":"2018-06-25T12:33:54","modified_gmt":"2018-06-25T12:33:54","slug":"fosfat-de-fludarabina","status":"publish","type":"wiki","link":"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/fosfat-de-fludarabina\/","title":{"rendered":"Fosfat de fludarabin\u0103"},"content":{"rendered":"<p>Fosfatul de fludarabin\u0103 este utilizat pentru a trata unele forme de leucemie, care nu r\u0103spund la alte terapii, sau care s-au agravat \u00een timpul altor tratamente.<\/p>\n<p>&nbsp;<\/p>\n<h2>Ce este Fosfatul de fludarabin\u0103?<\/h2>\n<p>&nbsp;<\/p>\n<p>Fosfatul de fludarabin\u0103 este un antimetabolit. El lucreaz\u0103 prin \u00eempiedicarea reproducerii celulelor canceroase, determin\u00e2nd astfel moartea lor.<\/p>\n<p>&nbsp;<\/p>\n<h2>Cum se administreaz\u0103 Fosfatul de fludarabin\u0103?<\/h2>\n<p>&nbsp;<\/p>\n<p>Fosfatul de fludarabin\u0103 se poate administra intravenos, prin injec\u021bie, sau pe cale oral\u0103, sub form\u0103 de tablete.<\/p>\n<p>&nbsp;<\/p>\n<h2>Efecte secundare asociate cu Fosfatul de fludarabin\u0103<\/h2>\n<p>&nbsp;<\/p>\n<p>Fludarabina poate reduce num\u0103rul trombocitelor \u0219i capacitatea de a lupta \u00eempotriva infec\u021biilor. Este, de asemenea, asociat\u0103 cu apari\u021bia cancerelor de piele (sau cu agravarea tumorilor de piele deja prezente), cu probleme severe de m\u0103duv\u0103 osoas\u0103, cu leucemia mieloid\u0103 acut\u0103 \u0219i cu leucoencefalopatie multifocal\u0103 progresiv\u0103. Fosfatul de fludarabin\u0103 poate provoca, de asemenea, infertilitate la b\u0103rba\u021bi.<\/p>\n<p>&nbsp;<\/p>\n<p>Printre celelalte posibile efecte secundare ale Fosfatului de fludarabin\u0103 se num\u0103r\u0103 urm\u0103toarele:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Diaree<\/li>\n<li>Stare general\u0103 proast\u0103<\/li>\n<li>Lipsa poftei de m\u00e2ncare<\/li>\n<li>Dureri musculare<\/li>\n<li>Grea\u021b\u0103<\/li>\n<li>Oboseal\u0103<\/li>\n<li>V\u0103rs\u0103turi<\/li>\n<li>Sl\u0103biciune<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Este important s\u0103 consulta\u021bi medicul dac\u0103 medicamentul declan\u0219eaz\u0103:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Eczem\u0103<\/li>\n<li>Urticarie<\/li>\n<li>M\u00e2nc\u0103rime<\/li>\n<li>Dificult\u0103\u021bi de respira\u021bie<\/li>\n<li>Presiune toracic\u0103<\/li>\n<li>Inflamarea gurii, a fe\u021bei, a buzelor sau a limbii<\/li>\n<li>G\u00e2nduri ciudate<\/li>\n<li>Scaune \u00eenchise la culoare sau cu s\u00e2nge<\/li>\n<li>Urin\u0103 \u00eenchis\u0103 la culoare sau cu s\u00e2nge<\/li>\n<li>Dificult\u0103\u021bi la mers<\/li>\n<li>Dureri \u00een piept<\/li>\n<li>Confuzie<\/li>\n<li>Tuse sau v\u0103rs\u0103turi cu s\u00e2nge<\/li>\n<li>Probleme de urinare<\/li>\n<li>Le\u0219in<\/li>\n<li>Pierderea auzului<\/li>\n<li>B\u0103t\u0103i neregulate ale inimii<\/li>\n<li>Durere la spate sau la \u0219olduri<\/li>\n<li>Schimb\u0103ri de dispozi\u021bie sau comportament<\/li>\n<li>Sl\u0103biciune sau crampe musculare<\/li>\n<li>Amor\u021beal\u0103 sau furnic\u0103turi ale m\u00e2inilor sau picioarelor<\/li>\n<li>Exfolierea, cojirea, \u00eenro\u0219irea sau inflamarea pielii<\/li>\n<li>Convulsii<\/li>\n<li>Oboseal\u0103 sau sl\u0103biciune sever\u0103 sau persistent\u0103<\/li>\n<li>Respira\u021bie dificil\u0103<\/li>\n<li>Febr\u0103, frisoane, tuse sau durere \u00een g\u00e2t<\/li>\n<li>Inflamarea degetelor, a m\u00e2inilor sau a picioarelor<\/li>\n<li>R\u0103ni la gur\u0103, buze sau limb\u0103<\/li>\n<li>V\u00e2n\u0103t\u0103i sau s\u00e2ngerare<\/li>\n<li>Probleme de vedere sau orbire<\/li>\n<li>V\u0103rs\u0103turi asem\u0103n\u0103toare cu cafeaua<\/li>\n<li>Icter<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>Contraindica\u021bii \u0219i avertismente asociate cu utilizarea de Fosfat de fludarabin\u0103<\/h2>\n<p>&nbsp;<\/p>\n<p>Fosfatul de fludarabin\u0103 poate compromite capacitatea de a conduce vehicule sau de a opera utilaje periculoase, \u00een special ce administreaz\u0103 \u00eempreun\u0103 cu alcoolul sau alte medicamente. Nu trebuie administrat \u00eempreun\u0103 cu pentostatina sau \u00een caz de insuficien\u021b\u0103 renal\u0103 sever\u0103.<\/p>\n<p>&nbsp;<\/p>\n<p>\u00cenainte de \u00eenceperea tratamentului cu Fosfat de fludarabin\u0103, este de asemenea important s\u0103 informa\u021bi medicul dac\u0103:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Ave\u021bi vreo alergie la substan\u021ba activ\u0103, la excipien\u021bii acesteia sau la alte medicamente sau alimente<\/li>\n<li>Lua\u021bi orice alte medicamente, remedii pe baz\u0103 de plante sau suplimente; se vor men\u021biona \u00een special: pentostatina \u0219i digoxina<\/li>\n<li>Suferi\u021bi (sau a\u021bi suferit) de probleme la m\u0103duv\u0103 osoas\u0103 sau de s\u00e2nge, tulbur\u0103ri hemoragice, afec\u021biuni renale, tulbur\u0103ri ale sistemului imunitar, probleme ale sistemului nervos, infec\u021bii, cancer de piele sau anemie hemolitic\u0103 autoimun\u0103<\/li>\n<li>A\u021bi fost testat pozitiv la testul Coombs<\/li>\n<li>Sunte\u021bi supus (sau a\u021bi urmat) chimioterapie sau radioterapie<\/li>\n<li>V\u0103 confrunta\u021bi cu reac\u021bii autoimune la administrarea de fosfat de fludarabin\u0103<\/li>\n<li>A\u021bi f\u0103cut recent o transfuzie de s\u00e2nge<\/li>\n<li>Sunte\u021bi \u00eens\u0103rcinat\u0103 sau al\u0103pta\u021bi<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u00cen timpul tratamentului cu Fosfat de fludarabin\u0103, este important s\u0103 nu se administreze vaccinuri vii. \u00cen cazul unor simptome precum v\u0103rs\u0103turi sau diaree, este vital s\u0103 v\u0103 hidrata\u021bi.<\/p>\n<p>&nbsp;<\/p>\n<p>Nu \u00een ultimul r\u00e2nd, este necesar\u0103 utilizarea de metode contraceptive timp de p\u00e2n\u0103 la 6 luni dup\u0103 \u00eencetarea tratamentului cu fosfat de fludarabin\u0103.<\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","wiki-categories":[1869],"wiki-types":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fosfat de fludarabin\u0103 - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanitas.net\/ro\/wiki\/ingrediente-active\/fosfat-de-fludarabina\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fosfat de fludarabin\u0103 - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Fosfatul de fludarabin\u0103 este utilizat pentru a trata unele forme de leucemie, care nu r\u0103spund la alte terapii, sau care s-au agravat \u00een timpul altor tratamente. &nbsp; Ce este Fosfatul de fludarabin\u0103? &nbsp; Fosfatul de fludarabin\u0103 este un antimetabolit. 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